ZIP

£125.00 1mg

SKU: KS-170 Categories: ,

Protein kinase Mζ inhibitor.

ZIP, or Zeta inhibitory peptide, is a cell permeable pseudo-substrate inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ induced synaptic potentiation in hippocampal slices in vitro and is widely used to investigate memory in a variety of learning tasks, including spatial sensitization, pain sensitization, fear-associated memories, conditioned taste aversion and development of locomotor sensitization in rodents. However, LTP and LTM are unaffected in both constitutive and conditional PKMζ knock-out mice, yet both are still impaired by ZIP application, suggesting another mechanism of action which may involve ionotropic glutamate AMPA receptors (AMPARs).

Please contact us for availability.

Additional information

Other Names

z-Pseudosubstrate inhibitory peptide, Zeta inhibitory peptide, PKCζ (113-125), myristoylated

Three Letter Sequence

Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Molecular Weight

1928.4

Molecular Formula

C90H154N30O17

Sequence

Myr-SIYRRGARRWRKL

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal myristoyl

Searchable Words

ZIP, 863987-12-6, Myr-SIYRRGARRWRKL, z-Pseudosubstrate inhibitory peptide, PKCζ (113-125), myristoylated, KS-170, KS170