WKYMVm
£75.00 1mg
FPR1, FPR2 and FPR3 receptor agonist.
WKYMVm is a selective agonist for formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) when expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. WKYMVm has pleiotropic anti-inflammatory, pro-angiogenic, anti-apoptotic and immunomodulatory effects in various animal models of sepsis, ulcerative colitis, myocardial infarction, ischemic hindlimb and diabetic cutaneous wound healing.
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Additional information
| Other Names | Leukocyte chemoattractant peptide |
|---|---|
| Three Letter Sequence | H-Trp-Lys-Tyr-Met-Val-D-Met-NH2 |
| Molecular Weight | 856.11 |
| Molecular Formula | C41H61N9O7S2 |
| Sequence | WKYMVm-NH2 |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Methionine 6 is D-Met, C-terminal amide |
| Searchable Words | WKYMVm, 187986-17-0, Leukocyte chemoattractant peptide, FR-010 |