WKYMVM
£55.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
FPR1, FPR2 and FPR3 receptor agonist.
WKYMVm is a selective agonist for formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) when expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. WKYMVm has pleiotropic anti-inflammatory, pro-angiogenic, anti-apoptotic and immunomodulatory effects in various animal models of sepsis, ulcerative colitis, myocardial infarction, ischemic hindlimb and diabetic cutaneous wound healing.
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Additional information
Other Names | Leukocyte chemoattractant peptide |
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Three Letter Sequence | H-Trp-Lys-Tyr-Met-Val-D-Met-NH2 |
Molecular Weight | 856.11 |
Molecular Formula | C41H61N9O7S2 |
Sequence | WKYMVm-NH2 |
Solubility | Soluble to 2 mg/ml in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Purity | >95% by HPLC |
Modifications | Methionine 6 is D-Met, C-terminal amide |
Searchable Words | WKYMVm, 187986-17-0, Leukocyte chemoattractant peptide, FR-010 |