VnP-16

£125.00 1mg

1 and v3 integrin signalling modulator.

VnP-16 is a peptide corresponding to residues 270-281 of human vitronectin, which exerts an anti-osteoporotic effect via 1 and v3 integrin signalling. VnP-16 promotes bone formation by accelerating osteoblast differentiation through direct interaction with 1 integrin followed by FAK activation, while inhibiting bone resorption through restraint of JNK-c-Fos-NFATc1 induced osteoclast differentiation and v3 integrin-c-Src-PYK2 mediated resorption. In a mouse model of estrogen deficiency induced osteoporosis, VnP-16 reverses ovariectomy induced bone loss by increasing osteoblast differentiation and promoting bone formation, while decreasing osteoclastogenesis and inhibiting bone resorption.

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SKU: IG-060 Categories: ,

Additional information

Other Names

Vitronectin derived bioactive peptide

Three Letter Sequence

H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2

Molecular Weight

1648.85

Molecular Formula

C82H112N20O17

Sequence

RVYFFKGKQYWE-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

VnP-16, IG-060, IG060, IG 060, VnP16, VnP 16, RVYFFKGKQYWE-NH2, Vitronectin derived bioactive peptide