Blocks PD-1/PD-L1 interaction.

TPP-1 is a peptide identified through bacterial surface display which binds specifically to programmed cell death ligand 1 (PD-L1), and blocks programmed cell death protein 1 (PD-1)/PD-L1 interaction. TPP-1 binds to free PD-L1 and also cells that express PD-L1 on their cell membranes, and can reverse PD-L1 mediated inhibition of T-cell activation, and inhibit human tumour growth via a T-cell dependent mechanism. In xenograft mouse models, tumour growth in TPP-1 treated mice was 56% – 71% lower than that in controls.

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