Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Blocks PD-1/PD-L1 interaction.

TPP-1 is a peptide identified through bacterial surface display which binds specifically to programmed cell death ligand 1 (PD-L1), and blocks programmed cell death protein 1 (PD-1)/PD-L1 interaction. TPP-1 binds to free PD-L1 and also cells that express PD-L1 on their cell membranes, and can reverse PD-L1 mediated inhibition of T-cell activation, and inhibit human tumour growth via a T-cell dependent mechanism. In xenograft mouse models, tumour growth in TPP-1 treated mice was 56% – 71% lower than that in controls.

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