TNIIIA2

£135.00 1mg

?1 integrin activator

TNIIIA2 is a peptide derived from the matricellular protein tenascin-C, a protein which is highly expressed in inflammatory bowel diseases including colorectal cancer, where tenascin-C expression level is correlated with poor prognosis.  TNIIIA2 induces potent and sustained activation of  ?1 integrin and promotes invasion and metastasis in colon cancer cells, and causes acquisition of aggressive behaviour, dysregulated proliferation, and migration in glioblastoma cells.   In an osteoarthritis mouse model, TNIIIA2 upregulates the expression of tumour necrosis factor-α, matrix metalloproteinase 3, and basic fibroblast growth factor and prevents articular cartilage degeneration without inducing synovitis.

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SKU: IG-070 Categories: ,

Additional information

Three Letter Sequence

H-Arg-Ser-Thr-Asp-Leu-Pro-Gly-Leu-Lys-Ala-Ala-Thr-His-Tyr-Thr-Ile-Thr-Ile-Arg-Gly-Val-Cys-OH

Molecular Weight

2373.73

Molecular Formula

C103H173N31O31

Sequence

RSTDLPGLKAATHYTITIRGVC

Solubility

Soluble in saline

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC