TLCK

£55.00 50mg

Serine protease inhibitor.

TLCK is a trypsin-like serine protease inhibitor which can block lipopolysaccharide (LPS)- or cytokine-induced activation of nuclear factorB (NF-κB), which, in turn blocks the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) transcription. TLCK blocks activation of pp70s6k by all mitogens and prevents apoptosis in cell lines by inhibiting caspase processing. TLCK has been used in chymotrypsin purification to prevent binding of trypsins to the affinity support, as a protease inhibitor in tissue and cell homogenization and as a trypsin inhibitor to determine specific protease activity levels.

Please contact us for availability.

SKU: PI-210 Categories: ,

Additional information

Three Letter Sequence

(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride

Molecular Weight

369.31

Molecular Formula

C14H21ClN2O3S · HCl

Sequence

(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride

Solubility

Soluble in water

Appearance

Off white powder

Storage

Store desiccated, frozen and in the dark

Purity

‰¥96% (TLC)