TFLLR-NH2
£60.00 1mg
PAR1 selective agonist.
TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-? secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.
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Additional information
| Other Names | PAR1-AP |
|---|---|
| Three Letter Sequence | Thr-Phe-Leu-Leu-Arg-NH2 |
| Molecular Weight | 647.82 |
| Molecular Formula | C31H53N9O6 |
| Sequence | TFLLR-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | TFLLR-NH2, 197794-83-5, TFLLR, PAR1-AP |