TFLLR-NH2

£60.00 1mg

PAR1 selective agonist.

TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-? secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.

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SKU: PR-040 Categories: ,

Additional information

Other Names

PAR1-AP

Three Letter Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Molecular Weight

647.82

Molecular Formula

C31H53N9O6

Sequence

TFLLR-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

TFLLR-NH2, 197794-83-5, TFLLR, PAR1-AP