TFLLR-NH2
£60.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
PAR1 selective agonist.
TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-? secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.
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Additional information
| Other Names | PAR1-AP |
|---|---|
| Three Letter Sequence | Thr-Phe-Leu-Leu-Arg-NH2 |
| Molecular Weight | 647.82 |
| Molecular Formula | C31H53N9O6 |
| Sequence | TFLLR-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | TFLLR-NH2, 197794-83-5, TFLLR, PAR1-AP |