TAT-QFNP12

£145.00 1mg

NDRG2 – PPM1A binding blocker.

TAT-QFNP12 is a peptide corresponding to the 302 to 313 amino acid domain of the protein phosphatase PPM1A, made cell permeable by the addition of TAT, and is a key fragment involved in the binding of PPM1A to the cytoplasmic protein NDRG2. TAT-QFNP12 blockade of the binding of NDRG2 with PPM1A allows PPM1A to enter the nucleus and dephosphorylate Smad2/3, preventing transcription and production of matrix metalloproteinase 9 (MMP-9). Unwanted increased levels of MMP-9 have an important part in blood-brain barrier (BBB) injury in subarachnoid haemorrhage (SAH) and can critically exacerbate poor prognosis. In mouse models of SAH, TAT-QFNP12 dose-dependently inhibits MMP-9 expression and Smad2/3 phosphorylation, and significantly reduces brain edema and neurological deficits, demonstrating that TAT-QFNP12 can protect the blood-brain barrier after SAH and alleviate secondary nerve injury.

Please contact us for availability.

SKU: PP-400 Categories: ,

Additional information

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Val-Lys-Lys-Glu-Ala-Glu-Leu-Asp-Lys-Tyr-Leu-Glu-OH

Molecular Weight

3004.73

Molecular Formula

C130H225N47O35

Sequence

YGRKKRRQRRRVKKEAELDKYLE

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

PP-400, PP400, TAT-QFNP12