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TAT-CBD3A6K

£145.00 1mg

SKU: PP-150 Categories: ,

Optimised variation of CBD3.

TAT-CBD3A6K is an optimised variation of CBD3, the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2), which is a modulator of N-type voltage-gated calcium channels (CaV2.2), conjugated to the cell penetrating motif of the HIV transduction domain protein TAT. TAT-CBD3A6K binds with greater affinity to Ca2+ channels and is more stable and less prone to unfolding than the parent peptide. TAT-CBD3A6K is anti-nociceptive in a rodent model of AIDS therapy-induced peripheral neuropathy.

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Additional information

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Lys-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH
Molecular Weight

3249.87
Molecular Formula

C137H250N60O32
Sequence

YGRKKRRQRRRARSRLKELRGVPRGL
Solubility

Soluble in DMSO
Appearance

Freeze dried solid
Storage

Store desiccated, frozen and in the dark
Purity

>95% by HPLC
Searchable Words

TAT-CBD3A6K, axonal collapsin response mediator protein 2, CRMP-2), N-type voltage-gated calcium channels, CaV2.2, nociceptive , H-YGRKKRRQRRRARSRLKELRGVPRGL-OH, YGRKKRRQRRRARSRLKELRGVPRGL, PP-150