TAT-CBD3A6K
£145.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Optimised variation of CBD3.
TAT-CBD3A6K is an optimised variation of CBD3, the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2), which is a modulator of N-type voltage-gated calcium channels (CaV2.2), conjugated to the cell penetrating motif of the HIV transduction domain protein TAT. TAT-CBD3A6K binds with greater affinity to Ca2+ channels and is more stable and less prone to unfolding than the parent peptide. TAT-CBD3A6K is anti-nociceptive in a rodent model of AIDS therapy-induced peripheral neuropathy.
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Additional information
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Lys-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH |
|---|---|
| Molecular Weight | 3249.87 |
| Molecular Formula | C137H250N60O32 |
| Sequence | YGRKKRRQRRRARSRLKELRGVPRGL |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | TAT-CBD3A6K, axonal collapsin response mediator protein 2, CRMP-2), N-type voltage-gated calcium channels, CaV2.2, nociceptive , H-YGRKKRRQRRRARSRLKELRGVPRGL-OH, YGRKKRRQRRRARSRLKELRGVPRGL, PP-150 |