T2857W

KIX-MLL interaction inhibitor.

T2857W is a kinase-inducible domain interacting (KIX) inhibitor designed from a peptide fragment corresponding to the transactivation domain (TAD) of the transcriptional activator, mixed-lineage leukemia protein (MLL). The KIX domain is an integral part of the general transcriptional coactivator CREB binding protein, and has been associated with leukemia, cancer, and various
viral diseases. KIX is a small globular domain with two binding sites, the c-Myb site and MLL site, which bind the transcriptional activators c-Myb and MLL, respectively. T2857W is the mutant of the MLL TAD peptide identified as having the highest binding affinity for KIX from a series, with a two-fold higher affinity for KIX than the wild-type MLL, and is effective in inhibiting the KIX-MLL interaction. T2857W also shows some selectivity for the MLL-KIX interaction over the c-Myb-KIX interaction.

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SKU: PP-450 Categories: ,

Additional information

Other Names

T2857W mutant of the MLL TAD peptide

Three Letter Sequence

H-Pro-Ser-Asp-Ile-Met-Asp-Phe-Val-Leu-Lys-Asn-Trp-OH

Molecular Weight

1463.71

Molecular Formula

C68H101N15O19S

Sequence

PSDIMDFVLKNW

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

.95% by hplc