T100-Mut

£175.00 1mg

Enhances the association of TRPA1 and TRPV1.

T100-Mut is a cell permeable peptide which enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1 associated pain. The design of T100-Mut originated from Tmem100, a 134-amino acid protein found in dorsal root ganglia (DRG), co-expressed with TRPA1 and TRPV1 with which it forms a complex. Tmem100 decreases the interaction between TRPA1 and TRPV1, whereas a Tmem100 mutant, Tmem100-3Q, exerts the opposite effect and enhances the association of TRPA1 and TRPV1 to inhibit TRPA1. T100-Mut contains the C-terminal sequence of Tmem100-3Q and mimicks the effect of full-length Tmem100-3Q, inhibiting TRPA1-mediated activity and pain in a TRPV1-dependent manner. T100-Mut is also effective in animal models of pain.

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SKU: PP-190 Categories: ,

Additional information

Three Letter Sequence

Myr-Trp-Lys-Val-Arg-Gln-Arg-Asn-Lys-Lys-Val-Gln-Gln-Gln-Glu-Ser-Gln-Thr-Ala-Leu-Val-Val-Asn-Gln-Arg-Cys-Leu-Phe-Ala-OH

Molecular Weight

2451.8

Molecular Formula

C109H186N34O30

Sequence

Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

Myristoyl group at N terminal

Searchable Words

T100-Mut, Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA-OH, WKVRQRNKKVQQQESQTALVVNQRCLFA