T100-Mut

£175.00 1mg

SKU: PP-190 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Enhances the association of TRPA1 and TRPV1.

T100-Mut is a cell permeable peptide which enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1 associated pain. The design of T100-Mut originated from Tmem100, a 134-amino acid protein found in dorsal root ganglia (DRG), co-expressed with TRPA1 and TRPV1 with which it forms a complex. Tmem100 decreases the interaction between TRPA1 and TRPV1, whereas a Tmem100 mutant, Tmem100-3Q, exerts the opposite effect and enhances the association of TRPA1 and TRPV1 to inhibit TRPA1. T100-Mut contains the C-terminal sequence of Tmem100-3Q and mimicks the effect of full-length Tmem100-3Q, inhibiting TRPA1-mediated activity and pain in a TRPV1-dependent manner. T100-Mut is also effective in animal models of pain.

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Additional information

Three Letter Sequence

Myr-Trp-Lys-Val-Arg-Gln-Arg-Asn-Lys-Lys-Val-Gln-Gln-Gln-Glu-Ser-Gln-Thr-Ala-Leu-Val-Val-Asn-Gln-Arg-Cys-Leu-Phe-Ala-OH

Molecular Weight

2451.8

Molecular Formula

C109H186N34O30

Sequence

Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

Myristoyl group at N terminal

Searchable Words

T100-Mut, Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA-OH, WKVRQRNKKVQQQESQTALVVNQRCLFA