Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Endogenous neurokinin-1 receptor (NK1R) agonist.

Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.

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