ssK36
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
SET domain containing protein 2 (SETD2) super substrate.
ssK36, or ssK36 (29 ?43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding.
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Additional information
| Other Names | ssK36 (29 “43) |
|---|---|
| Three Letter Sequence | H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH |
| Molecular Weight | 1771 |
| Molecular Formula | C79H127N29O18 |
| Sequence | APRFGGVKRPNRYRP |
| Solubility | Soluble in water and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | ssK36, APRFGGVKRPNRYRP, H-APRFGGVKRPNRYRP-OH, ssK36 (29 “43), SETD2, substrate, SP-010, SP010 |