SLIGKV-NH2
£55.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Protease activated receptor 2 (PAR2) agonist.
SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist with a Ki of 9.64 μM and an IC50 of 10.4 μM. SLIGKV-NH2 corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2 and like other peptides corresponding to the tethered ligand sequences of the thrombin receptor and PAR-2 receptor is a full agonist and can be used to investigate receptor function. SLIGKV-NH2 stimulates lactoferrin and IL-8 secretion from human neutrophils.
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Additional information
| Three Letter Sequence | H-Ser-Leu-Ile-Gly-Lys-Val-NH2 |
|---|---|
| Molecular Weight | 614.78 |
| Molecular Formula | C28H54N8O7 |
| Sequence | SLIGKV-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide) |
| Searchable Words | SLIGKV-NH2, 190383-13-2 |