SFFLRN-NH2
£85.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Protease activated receptor-1 (PAR-1) activator.
SFFLRN-NH2 is the tethered ligand domain sequence of murine protease-activated receptor-1 (PAR-1), the G protein-coupled receptor highly expressed in platelets and endothelial cells and one of four protease-activated receptors involved in the regulation of the thrombotic response. SFFLRN-NH2 activates PAR-1 and induces relaxant responses of mouse isolated tracheal smooth muscle preparations which are mediated by prostaglandins.
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Additional information
| Other Names | SFLLRN-amide |
|---|---|
| Three Letter Sequence | H-Ser-Phe-Phe-Leu-Arg-Asn-NH2 |
| Molecular Weight | 781.9 |
| Molecular Formula | C37H55N11O8 |
| Sequence | SFFLRN-NH2 |
| Solubility | Soluble in water to 1mg per ml |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide |
| Searchable Words | SFFLRN-amide, thrombin receptor agonist peptide, SFFLRN-NH2, tethered ligand domain sequence of murine protease-activated receptor-1, PAR-1, H-SFFLRN-NH2, PR-110 |