SFFLRN-NH2
£85.00 1mg
Protease activated receptor-1 (PAR-1) activator.
SFFLRN-NH2 is the tethered ligand domain sequence of murine protease-activated receptor-1 (PAR-1), the G protein-coupled receptor highly expressed in platelets and endothelial cells and one of four protease-activated receptors involved in the regulation of the thrombotic response. SFFLRN-NH2 activates PAR-1 and induces relaxant responses of mouse isolated tracheal smooth muscle preparations which are mediated by prostaglandins.
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Additional information
| Other Names | SFLLRN-amide |
|---|---|
| Three Letter Sequence | H-Ser-Phe-Phe-Leu-Arg-Asn-NH2 |
| Molecular Weight | 781.9 |
| Molecular Formula | C37H55N11O8 |
| Sequence | SFFLRN-NH2 |
| Solubility | Soluble in water to 1mg per ml |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide |
| Searchable Words | SFFLRN-amide, thrombin receptor agonist peptide, SFFLRN-NH2, tethered ligand domain sequence of murine protease-activated receptor-1, PAR-1, H-SFFLRN-NH2, PR-110 |