Rytvela

£125.00 1mg

IL-1 receptor allosteric antagonist.

Rytvela is an all D peptide derived from an extracellular loop region of the interleukin-1 receptor accessory protein (IL-1RAcP), which acts as an allosteric negative modulator of the ?interleukin-1 receptor (IL-1R). In vitro, rytvela is specific, potent and effective and blocks human thymocyte proliferation with an IC50 of 1 nM, Rytvela does not significantly inhibit NF-κB, but instead it selectively inhibits the IL-1R downstream stress associated protein kinases/transcription factor c-jun and Rho GTPase/Rho-associated coiled coil containing protein kinase signalling pathways. In vivo rytvela is active in models of hyperthermia and inflammatory bowel disease and topically in contact dermatitis. A scrambled control peptide, rytvela scrambled peptide, is also available.

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SKU: CY-030 Categories: ,

Additional information

Other Names

101.1

Three Letter Sequence

H-(D)Arg-(D)Tyr-(D)Thr-(D)Val-(D)Glu-(D)Leu-(D)Ala-OH

Molecular Weight

850.96

Molecular Formula

C38H62N10O12

Sequence

rytvela

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

All amino acids are D isomers

Searchable Words

868844-53-5, rytvela, CY030, CY-030, 101.10