RW3

£125.00 1mg

Antimicrobial and antifungal.

RW3 is a short peptide containing repeating arginine (R) and tryptophan (W) residues which has been shown to possess antimicrobial and antifungal activity with low cytotoxicity. The positively charged arginine interacts with the bacterial membrane through electrostatic attraction whereas the non-polar tryptophan residue interacts with the lipid bilayer. These two properties allow RW3 to interact with the bacterial membrane, resulting in membrane destabilization and pore formation and bacterial cell death. RW3 has been shown to have enhanced activity in combination with other antimicrobial agents.

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SKU: AM-150 Categories: ,

Additional information

Three Letter Sequence

H-Arg-Trp-Arg-Trp-Arg-Trp-NH2

Molecular Weight

1044.2

Molecular Formula

C51H69N19O6

Sequence

RWRWRW-NH2

Solubility

Soluble in dilute acid and physiological buffers

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

H-RWRWRW-NH2, RWRWRW-NH2, RW3, RWRWRW, antimicrobial, antifungal, membrane destabilization, pore formation , RW 3, AM-150, AM150