RMR

£95.00 1mg

Disrupts PAK1 RUNX3 interaction.

RMR is a peptide derived from the protein sequence flanking the threonine 209 phosphorylation site of the Runt-related transcription factor 3 (RUNX3) protein, chosen based on docking efficiency with the active site of P21 Activated Kinase 1 (PAK1), and ability to displace PAK1 RUNX3 interaction in models. PAK1 is an oncogenic serine/threonine kinase which modulates several signalling pathways involved in cancer, and phosphorylation of RUNX3 at T209 by PAK1 switches the function of RUNX3 from tumour suppressor to oncogene. RMR peptide is stable in vitro and in vivo, non toxic to normal cells, and inhibits threonine 209 phosphorylation in RUNX3 by PAK1. In cell culture models RMR peptide reduces proliferation of human oral squamous cell carcinoma samples, and in vivo causes 33% tumour regression in tumour xenograft models.

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SKU: PP-440 Categories: ,

Additional information

Other Names

RMR peptide

Three Letter Sequence

H-Arg-Met-Arg-Val-Thr-Pro-Ser-Thr-Pro-Ser-Pro-Arg-OH

Molecular Weight

1383.74

Molecular Formula

C57H101N21O17S

Sequence

RMRVTPSTPSPR

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

PP-440, PP440, RMRVTPSTPSPR, RMR