Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Rice derived peptide able to improve cognitive decline.

Rice-memolin is a peptide generated by thermolysin digestion of rice bran that can improve cognitive decline. Rice-memolin corresponds to fragments of three rice protein sequences and appears to be resistant to gut proteases. In male ddY mice, rice-memolin improves cognitive decline induced by short-term high fat diet intake after oral administration in two behaviour tests, an effect inhibited by injection of methyllycaconitine (MLA), suggesting that rice-memolin acts through 7nAChR nicotinic receptors. Rice memolin also increases neurogenesis and expression of neurotrophic factors in the hippocampus and reduces blood glucose. Rice-memolin has no effect on hippocampal mRNA expression of inflammatory cytokines such as tumour necrosis factor-?, interleukin (IL)-1?, IL-1?, and IL-6. Rice-memolin is the first rice-bran-derived peptide able to improve cognitive decline.

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