[Pyr1]-Apelin 13
£55.00 1mg
Endogenous agonist for the apelin APJ receptor.
[Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.
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Additional information
| Other Names | [Pyr1]-Apelin 13, [pGlu1]-apelin-13 |
|---|---|
| Three Letter Sequence | Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
| Molecular Weight | 1533.8 |
| Molecular Formula | C69H109N22O16S |
| Sequence | XRPRLSHKGPMPF |
| Solubility | Soluble in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | X is pGlu |
| Searchable Words | [Pyr1]-Apelin 13, [pGlu1]-apelin-13, pyroglutamyl, endogenous, apelin APJ receptor, 217082-60-5, Glp-RPRLSHKGPMPF-OH, Glp-RPRLSHKGPMPF, AR-020 |