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[Pyr1]-Apelin 13

[Pyr1]-Apelin 13

£55.00 1mg

SKU: AR-020 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Endogenous agonist for the apelin APJ receptor.

[Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.

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Additional information

Other Names

[Pyr1]-Apelin 13, [pGlu1]-apelin-13
Three Letter Sequence

Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
Molecular Weight

1533.8
Molecular Formula

C69H109N22O16S
Sequence

XRPRLSHKGPMPF
Solubility

Soluble in dilute acid and physiological buffers
Appearance

Freeze dried solid
Storage

Store dry, frozen and in the dark
Purity

>95% by HPLC
Modifications

X is pGlu
Searchable Words

[Pyr1]-Apelin 13, [pGlu1]-apelin-13, pyroglutamyl, endogenous, apelin APJ receptor, 217082-60-5, Glp-RPRLSHKGPMPF-OH, Glp-RPRLSHKGPMPF, AR-020