P32/98

£85.00 10mg

Dipeptidyl peptidase IV (DPP IV) inhibitor.

P32/98, also known as isoleucyl thiazolidide, is a potent and selective cell permeable inhibitor of dipeptidyl peptidase IV (DPP IV) with a Ki of 130 nM. P32/98 inhibition of DPP IV prevents degradation of both gastric inhibitory peptide (GIP) and Glucagon-like peptide-1, enhancing insulin secretion. P32/98 improves glucose tolerance, insulin sensitivity and beta-cell glucose responsiveness in diabetic fatty rats following oral administration.

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SKU: PI-090 Categories: ,

Additional information

Other Names

Isoleucyl thiazolidide

Three Letter Sequence

(2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate

Molecular Weight

260.35

Molecular Formula

C9H18N2OS 1/2C4H4O4

Sequence

(2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemifumarate

Solubility

Soluble in DMSO or in water (up to 20 mg/ml).

Appearance

White solid

Storage

Store desiccated, frozen and in the dark

Purity

98% by TLC