Orexin A (Human, Rat, Mouse)

£145.00 0.5mg

Endogenous OX1 and OX2 orexin receptor agonist.

Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.

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SKU: OX-050 Categories: ,

Additional information

Other Names

Hypocretin 1

Three Letter Sequence

Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14)

Molecular Weight

3561.12

Molecular Formula

C152H243N47O44S4

Sequence

XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide

Searchable Words

Orexin A (human, rat, mouse), OX-050, XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2, 205640-90-0, hypocretin 1