Orexin A (human, rat, mouse)
£145.00 0.5mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Endogenous OX1 and OX2 orexin receptor agonist.
Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.
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Additional information
| Other Names | Hypocretin 1 |
|---|---|
| Three Letter Sequence | Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14) |
| Molecular Weight | 3561.12 |
| Molecular Formula | C152H243N47O44S4 |
| Sequence | XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide |
| Searchable Words | Orexin A (human, rat, mouse), OX-050, XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2, 205640-90-0, hypocretin 1 |