Orexin A (Human, Rat, Mouse)
£145.00 0.5mg
Endogenous OX1 and OX2 orexin receptor agonist.
Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.
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Additional information
| Other Names | Hypocretin 1 |
|---|---|
| Three Letter Sequence | Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14) |
| Molecular Weight | 3561.12 |
| Molecular Formula | C152H243N47O44S4 |
| Sequence | XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide |
| Searchable Words | Orexin A (human, rat, mouse), OX-050, XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2, 205640-90-0, hypocretin 1 |