Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Antimicrobial peptide derived from LL-37.

OP-145 is a synthetic antimicrobial peptide derived from amino acid sequence 13 36 of  human cathelicidin LL-37, further modified to favour the formation of an amphipathic helix. To improve stability against proteolytic degradation, the N-terminus is acetylated and the C-terminus amidated. OP-145 is a potent antibacterial, only lytic to human cells at high concentrations, and shows significant activity against nine methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing their growth and biofilm formation. OP-145 is safe and effective against chronic middle ear infection (otitis media) in humans, and when formulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, OP-145 exerts strong anti-biofilm effects on clinical isolated pathogens and exerts powerful anti-infection effects in vivo.

Please contact us for availability.