OP-145

£145.00 1mg

Antimicrobial peptide derived from LL-37.

OP-145 is a synthetic antimicrobial peptide derived from amino acid sequence 13 36 of  human cathelicidin LL-37, further modified to favour the formation of an amphipathic helix. To improve stability against proteolytic degradation, the N-terminus is acetylated and the C-terminus amidated. OP-145 is a potent antibacterial, only lytic to human cells at high concentrations, and shows significant activity against nine methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing their growth and biofilm formation. OP-145 is safe and effective against chronic middle ear infection (otitis media) in humans, and when formulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, OP-145 exerts strong anti-biofilm effects on clinical isolated pathogens and exerts powerful anti-infection effects in vivo.

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SKU: AM-360 Categories: ,

Additional information

Other Names

P60.4Ac

Three Letter Sequence

Ac-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2

Molecular Weight

3093.77

Molecular Formula

C142H246N46O31

Sequence

Ac-IGKEFKRIVERIKRFLRELVRPLR-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal acetyl, C terminal amide

Searchable Words

OP 145, OP145, OP-145, Ac-IGKEFKRIVERIKRFLRELVRPLR-NH2, 732984-81-5, P60.4Ac