Octpep-1

£95.00 1mg

Targets PI3K/AKT/mTOR signalling.

Octpep-1 is a peptide derived from the octopus kaurna, or the southern sand octopus, a species native to the seas around the Great Australian Bight and Tasmania. Octpep-1 disrupts PI3K/AKT/mTOR pathway signalling and selectively reduces the proliferative capacity of human melanoma BRAFV600E mutated cells, with minimal effects on fibroblasts. Octpep-1 has weak agonist activity at tachykinin NK1 receptors but its antiproliferative activity is independent of NK1R expression. Octpep-1 acts synergistically in combination with the mTORC1 inhibitor rapamycin or the ERK1/2 inhibitor LY3214996 to enhance its antiproliferative effects and augment cytotoxicity. Octpep-1 reduces the progression of tumours in vivo, being effective in xenograft mouse melanoma and zebrafish models.

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SKU: KS-240 Categories: ,

Additional information

Three Letter Sequence

H-Asp-Pro-Pro-Ser-Asp-Asp-Glu-Phe-Val-Ser-Leu-Met-OH

Molecular Weight

1350.56

Molecular Formula

C58H86N12O23S

Sequence

DPPSDDEFVSLM

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>98% by HPLC