NT1-20

£175.00 1mg

SKU: AS-010 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Blocks ASIC1a binding to RIPK1.

NT1-20 is a tatylated membrane penetrating peptide derived from the N-terminus of the acid sensing ion channel 1a (ASIC1a), which can block ASIC1a binding receptor interacting protein kinase 1 (RIPK1) to its C terminus. ASIC1a ?mediates necroptosis via recruiting RIPK1, independent of its ion-conducting function, and though this mechanism NT1-20 can protect neurons against acidosis induced necroptosis in vitro. NT1-20 can also reduce neuronal damage in mouse models of ischemic stroke.

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Additional information

Other Names

Peptide NT1 “20

Three Letter Sequence

H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Met-Glu-Leu-Lys-Thr-Glu-Glu-Glu-Glu-Val-Gly-Gly-Val-Gln-Pro-Val-Ser-Ile-Gln-Ala-OH

Molecular Weight

3655.22

Molecular Formula

C150H265N55O47S2

Sequence

GRKKRRQRRRCMELKTEEEEVGGVQPVSIQA

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

AS-010, NT1 “20, GRKKRRQRRRCMELKTEEEEVGGVQPVSIQA, NT1-20