NP1

£145.00 1mg

Inhibits activation of the NF-κ B pathway.

NP1 was identified from a 60 amino acid residue precursor encoded by a 297-bp cDNA sequence from the skin of the amphibian frog Rana limnocharis.  NP1 suppresses inflammation by reducing interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) levels, and also up-regulates expression of miR-6328, which in turn down regulates kappa B kinase β (IKKβ).  IKKβ reduces phosphorylation of nuclear factor-kappa B p65 (NF- κ B p65) and inhibits NF-κ B (I-κ B), inhibiting activation of the NF-κ B pathway.    In middle cerebral artery occlusion/reperfusion (MCAO/R) rats, NP1 reduces the volume of cerebral infarction and relieves neurological dysfunction.  NP1 can also significantly alleviate the decrease in viability and increase in apoptosis of neuron like PC12 cells induced by oxygen glucose deprivation/re-oxygenation (OGD/R).

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SKU: PP-460 Categories: ,

Additional information

Other Names

Neuroprotective Peptide 1

Three Letter Sequence

H-Phe-Leu-Pro-Ala-Ala-Ile-Cys*-Leu-Val-Ile-Lys-Thr-Cys*, disulphide bridge between cysteines 7 and 13

Molecular Weight

1389.8

Molecular Formula

C65H108N14O15S2

Sequence

FLPAAIC*LVIKTC*

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

> 95% by HPLC

Modifications

Disulphide bridge between cysteines 7 and 13