NP-12
£125.00 1mg
PD-1 – PD-L1 interaction blocker.
NP-12 is a branched peptide designed from analysis of the strands and loops of programmed cell death protein 1 (PD-1) at the interface of the PD-1/ programmed cell death ligand 1 (PD-L1) interaction. NP-12 binds to PD-L1 and is a functional equipotent antagonist of both PD-L1 and PD-L2 signalling. In preclinical models of melanoma, colon cancer, and kidney cancers, NP-12 showed significant efficacy in inhibiting primary tumour growth and metastasis. NP-12 shows antitumour activity in pre-established tumour models either as a single agent or when in combination with other immunologic cell death agents.
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Additional information
| Other Names | AUNP 12, AUR 012, PD-1 “derived peptide" |
|---|---|
| Three Letter Sequence | H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2 |
| Molecular Weight | 3261.55 |
| Molecular Formula | C142H226N40O48 |
| Sequence | SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2 |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide, amide bridge between Lys-8 and Phe-7 in branch chain |
| Searchable Words | NP12, NP-12, 1353563-85-5, AUNP 12, AUR 012, PP-300, PP300, SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2 |