Nociceptin

£55.00 1mg

Endogenous nociceptin receptor agonist.

Nociceptin/orphanin FQ (N/OFQ) is a 17-amino acid neuropeptide and an endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin is derived from the prepronociceptin protein, as also are nocistatin and NocII, which inhibit N/OFQ receptor function. The name nociceptin derives from the discovery that it can produce a pro-nociceptive response, and nociceptin acts as an anti-analgesic, counteracting the effect of pain-relievers. Nociceptin is widely distributed in the CNS and acts on numerous brain activities including pain sensation and fear. When administered to the spinal cord, nociceptin produces similar analgesic effects to the classical opioids.

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SKU: PN-010 Categories: ,

Additional information

Other Names

Orphanin FQ

Three Letter Sequence

H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH

Molecular Weight

1809

Molecular Formula

C79H129N27O22

Sequence

FGGFTGARKSARKLANQ

Solubility

Soluble in dilute acid and physiological buffers. Soluble in DMSO

Appearance

Freeze dried solid

Storage

We recommend storage desiccated, frozen and in the dark

Purity

‰¥95% by HPLC

Searchable Words

orphanin FQ, Nociceptin, neuropeptide, nociceptin receptor, NOP, ORL-1, antianalgesic, pain, analgesic , FGGFTGARKSARKLANQ, 170713-75-4, PN-010, PN010