Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Matrix metalloproteinase 3 (MMP-3) inhibitor.

NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3, stromelysin 1, progelatinase). Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation. NNGH additionally shows broad spectrum inhibition activity at other MMPs and is cell permeable.

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