Mca-RPKPVE-Nval-WR-K(Dnp)-NH2
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Fret substrate for MMP-3 and MMP-10.
Mca-RPKPVE-Nval-WRK(Dnp)-NH2, also known as Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, is an excellent substrate for MMP-3 (stromelysin 1) and MMP-10 (stromelysin 2), but not a substrate MMP-1 or MMP-2. Mca-RPKPVE-Nval-WRK(Dnp)-NH2 substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group. The cleavage site is the peptide bond between Glu and Nval (norvaline). Mca-RPKPVE-Nval-WRK(Dnp)-NH2 is also an excellent substrate for trypsin, HGF activator and factor Xa.
Please contact us for availability.
Additional information
| Other Names | Mca-RPKPVE-Nval-WRK(Dnp)-NH2 fluorogenic MMP substrate |
|---|---|
| Three Letter Sequence | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(Dnp)-NH2 |
| Molecular Weight | 1675.9 |
| Molecular Formula | C78H110N22O20 |
| Sequence | Mca-RPKPVEXWRK(Dnp)-NH2 |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | 7-methoxycoumarin (Mca) at the N terminal, X is norvaline, Lysine 10 is substuted with a 2,4-dinitrophenyl (Dnp) group, and the C terminal is amidated |
| Searchable Words | Mca-RPKPVE-Nval-WRK(Dnp)-NH2, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, substrate, MMP-3 , stromelysin 1, stromelysin 2, 7-methoxycoumarin, Mca, 2,4-dinitrophenyl (Dnp), PS-040, PS040 |