Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Broad spectrum antimicrobial.

Magainins are closely related 23 amino acid amphipathic cationic peptides with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainins 1 and magainin 2 are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2.

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