LRRKtide

£55.00 1mg

SKU: KS-010 Categories: ,

Leucine rich repeat kinase 2 (LRRK2) substrate.

LRRKtide is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM protein family members ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553), proteins which influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. LRRK2 is found in most organs and is involved in several cellular pathways. The LRRK2 gene and α-synuclein gene (SNCA) are the key influencing factors of Parkinson’s disease (PD), with dysfunction of LRRK2 influencing the accumulation of α-synuclein.

Additional information

Three Letter Sequence

H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln-OH

Molecular Weight

1931.28

Molecular Formula

C83H147N31O22

Sequence

RLGRDKYKTLRQIRQ

Solubility

Soluble in dilute acid

Appearance

Freeze dried solid

Storage

Store dark, frozen and desiccated

Purity

>95% by HPLC

Searchable Words

LRRKtide, peptide substrate, leucine-rich repeat kinase 2, LRRK2), ERM protein, ezrin, radixin, moesin (amino acids 539-553), Parkinson ™s disease, RLGRDKYKTLRQIRQ, KS-010, KS010