Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

EphA4 kinase inhibitor.

KYL is an EphA4 receptor tyrosine kinase inhibitor with a Kd of 0.8 μM. KYL inhibits EphA4-EphrinA5 interactions with an IC50 of 6.34 μM. Through EphA4 inhibition, KYL can prevent dendritic spine reduction, the blocking of LTP induction and neuronal apoptosis caused by amyloid-? oligomers (A?Os). EphA4-/- neurons or sh-EphA4-transfected neurons showed reduced synaptotoxicity by A?Os. EphA4/c-Abl activation is a key-signalling event that mediates the synaptic damage induced by A?Os.

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