KP1
£185.00 1mg
Disrupts TGF-?/T?R2 interaction.
KP1 is a peptide representing the sequence Phe57 to Lys86 of the anti-aging protein Klotho, and is one of the buried ?-strands in the N-terminal domain. KP1 mimics the anti-fibrotic action of Klotho by constraining TGF-? signaling, KP1 acts through binding to TGF-? receptor 2 (T?R2) and disrupting TGF-?/T?R2 interaction. KP1 inhibits multiple downstream TGF-? pathways including activation of Smad2/3 and mitogen activated protein kinases. In mouse models of renal fibrosis, KP1 preserves kidney function, ameliorates renal fibrosis and restores endogenous Klotho expression.
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Additional information
| Other Names | KP1 (human), Klotho-derived peptide 1 |
|---|---|
| Three Letter Sequence | H-Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly-OH |
| Molecular Weight | 3228.48 |
| Molecular Formula | C149H203N39O43 |
| Sequence | FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | KP1, FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG, PP-290, PP290, KP-1 |