KP1
£185.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Disrupts TGF-?/T?R2 interaction.
KP1 is a peptide representing the sequence Phe57 to Lys86 of the anti-aging protein Klotho, and is one of the buried ?-strands in the N-terminal domain. KP1 mimics the anti-fibrotic action of Klotho by constraining TGF-? signaling, KP1 acts through binding to TGF-? receptor 2 (T?R2) and disrupting TGF-?/T?R2 interaction. KP1 inhibits multiple downstream TGF-? pathways including activation of Smad2/3 and mitogen activated protein kinases. In mouse models of renal fibrosis, KP1 preserves kidney function, ameliorates renal fibrosis and restores endogenous Klotho expression.
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Additional information
| Other Names | KP1 (human), Klotho-derived peptide 1 |
|---|---|
| Three Letter Sequence | H-Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly-OH |
| Molecular Weight | 3228.48 |
| Molecular Formula | C149H203N39O43 |
| Sequence | FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | KP1, FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG, PP-290, PP290, KP-1 |