KLA peptide

£89.00 1mg

Proapoptotic mitochondrial membrane disruptor.

KLA peptide is an antimicrobial peptide with an amphipathic alpha-helical structure and the ability to disrupt mitochondrial membranes. KLA is an important anti-cancer peptide but has poor eukaryotic cell penetrating ability, and consequently requires the assistance of other cell penetrating peptides for effective translocation. Once KLA peptide is internalized into eukaryotic cells, it can destroy mitochondrial membranes and initiate the tumour cell apoptosis process, and many strategies have been employed to facilitate this. KLA peptide exhibits cytotoxicity against human breast cancer and other tumour cells in vivo, slowing tumour growth and extending survival time.

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SKU: AM-340 Categories: ,

Additional information

Other Names

(KLAKLAK)2, KLA, Proapoptotic peptide

Three Letter Sequence

H-Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys-NH2

Molecular Weight

1522.08

Molecular Formula

C72H139N21O14

Sequence

KLAKLAKKLAKLAK-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

180461-53-4, KLAKLAKKLAKLAK-NH2, (KLAKLAK)2, KLA, KLA peptide, Proapoptotic peptide, AM-340, AM340