IRBP (651-670) (Human)

£175.00 1mg

SKU: IM-050 Categories: ,

Residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP).

IRBP (651-670) (human), sometimes referred to as hIRBP651-670 or human IRBP651-670, is amino acid residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP), which has been identified as a new uveitogenic epitope. IRBP (651-670) (human) is uveitogenic for mice of the H-2b haplotype and elicits experimental autoimmune uveitis (EAU) with a higher severity and incidence in C57BL/6 mice than the previously characterized IRBP (1-20) (human) epitope. Co-immunization with IRBP (1-20) (human) and IRBP (651-670) human is additive but not synergistic. IRBP (651-670) (human) appears to be an epitope naturally processed from a conserved region of native IRBP.

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Additional information

Other Names

hIRBP651-670, human IRBP651-670

Three Letter Sequence

H-Leu-Ala-Gln-Gly-Ala-Tyr-Arg-Thr-Ala-Val-Asp-Leu-Glu-Ser-Leu-Ala-Ser-Gln-Leu-Thr-OH

Molecular Weight

2107.35

Molecular Formula

C91H151N25O32

Sequence

LAQGAYRTAVDLESLASQLT

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

IRBP (651-670) (human), hIRBP651-670, human IRBP651-670, epitope, immunology, human interphotoreceptor retinoid binding protein, IRBP, uveitogenic, experimental autoimmune uveitis, EAU, H-LAQGAYRTAVDLESLASQLT-OH, LAQGAYRTAVDLESLASQLT, IM-050, IM050