Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Innate defence regulator peptide.

IDR 1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR 1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR 1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signalling pathways. IDR 1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged with TLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged model of airway inflammation.

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