Hexa-D-arginine
£85.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Furin inhibitor.
Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
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Additional information
| Other Names | Hexa-d-arginine amide, D6R, Furin Inhibitor II |
|---|---|
| Three Letter Sequence | H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2 |
| Molecular Weight | 954.16 |
| Molecular Formula | C36H75N25O6 |
| Sequence | rrrrrr-NH2 |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide, arginines 1,2,3,4,5 and 6 are all D- configuration |
| Searchable Words | Hexa-D-arginine, rrrrrr-NH2, rrrrrr, 673202-67-0 |