Hexa-D-arginine

£85.00 1mg

Furin inhibitor.

Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.

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SKU: FN-010 Categories: ,

Additional information

Other Names

Hexa-d-arginine amide, D6R, Furin Inhibitor II

Three Letter Sequence

H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2

Molecular Weight

954.16

Molecular Formula

C36H75N25O6

Sequence

rrrrrr-NH2

Solubility

Soluble to 2 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide, arginines 1,2,3,4,5 and 6 are all D- configuration

Searchable Words

Hexa-D-arginine, rrrrrr-NH2, rrrrrr, 673202-67-0