Hexa-D-arginine
£85.00 1mg
Furin inhibitor.
Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
Please contact us for availability.
Additional information
| Other Names | Hexa-d-arginine amide, D6R, Furin Inhibitor II |
|---|---|
| Three Letter Sequence | H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2 |
| Molecular Weight | 954.16 |
| Molecular Formula | C36H75N25O6 |
| Sequence | rrrrrr-NH2 |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide, arginines 1,2,3,4,5 and 6 are all D- configuration |
| Searchable Words | Hexa-D-arginine, rrrrrr-NH2, rrrrrr, 673202-67-0 |