α-helical CRF (9-41)

£175.00 1mg

CRF antagonist.

α-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2 and mouse CRF2 receptors respectively. α-helical CRF (9-41) decreases anxiety-like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. α-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition.

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SKU: CR-010 Categories: ,

Additional information

Other Names

α-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9 “41)

Three Letter Sequence

H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

Molecular Weight

3827

Molecular Formula

C166H274N46O53S2

Sequence

DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2

Solubility

Soluble to 1 mg/ml in 0.1% TFA

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

α-helical CRF 9-41, α-helical CRF (9-41), 90880-23-2, AHCRF, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA