α-helical CRF (9-41)
£175.00 1mg
CRF antagonist.
α-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2 and mouse CRF2 receptors respectively. α-helical CRF (9-41) decreases anxiety-like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. α-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition.
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Additional information
| Other Names | α-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9 “41) |
|---|---|
| Three Letter Sequence | H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2 |
| Molecular Weight | 3827 |
| Molecular Formula | C166H274N46O53S2 |
| Sequence | DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2 |
| Solubility | Soluble to 1 mg/ml in 0.1% TFA |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | α-helical CRF 9-41, α-helical CRF (9-41), 90880-23-2, AHCRF, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA |