H10, biotinylated
£145.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Biotinylated version of anterior gradient 2 (AGR2) binding peptide H10.
H10, biotinylated is the N-terminal biotinylated version of the anterior gradient 2 (AGR2) binding peptide H10 (MKMQVRIYLV) which was identified by mRNA display from a complex (>1011) library. AGR2 is a cancer-associated protein and increased levels of extracellular AGR2 (eAGR2) have been correlated with poor prognosis in cancer patients, making it a potential biomarker. H10 possesses high affinity binding to AGR2 with a KD of 6.4 nM, and has been used as the capture reagent in an AGR2 ELISA. H10 can also inhibit cancer cell migration in breast and prostate cancer cell lines.
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Additional information
| Three Letter Sequence | Biotin-Gly-Gly-Gly-Ser-Gly-Met-Lys-Met-Gln-Val-Arg-Ile-Tyr-Leu-Val-OH |
|---|---|
| Molecular Weight | 1822.26 |
| Molecular Formula | C79H132N22O21S3 |
| Sequence | Biotin-GGGSGMKMQVRIYLV |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Biotinylated at N terminus |
| Searchable Words | H10, biotinylated, Biotin-GGGSGMKMQVRIYLV-OH, GGGSGMKMQVRIYLV, PP-010 |