Gap 27

£85.00 1mg

SKU: GJ-010 Categories: ,

Selective gap junction channel blocker.

Gap 27 is a connexin mimetic peptide corresponding to the SRPTEKTIFFI sequence (amino acids 204 214) on the second extracellular loop of connexin43 (Cx43) which is a selective and reversible inhibitor of Cx43 mediated cell communication, which does not influence Cx43 expression levels. Gap27 effectively inhibits gap junction coupling at concentrations of 50 μM in keratinocytes and HeLa43 cells and is a versatile inhibitor of connexin-mediated communication in tissue networks, having been used to identify the role of connexins in cardiomyocyte activities and in pathological processes such as epilepsy.

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Additional information

Other Names

Connexin43 mimetic peptide, GAP 27, Connexin mimetic peptide, CMP

Three Letter Sequence

H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH

Molecular Weight

1304.55

Molecular Formula

C60H101N15O17

Sequence

SRPTEKTIFII

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

Gap 27, 198284-64-9, SRPTEKTIFII