Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Non acylated form of ghrelin.

[Des-octanoyl]-Ghrelin (human) is the more stable, non-acylated and major circulating isoform of ghrelin (human ), with a half-life of 35 min in plasma compared with 10 minutes for acylated ghrelin. Unlike ghrelin, [des-octanoyl]-ghrelin (human) does not bind to the ghrelin receptor (GHS-R1a), or induce growth hormone release. [Des-octanoyl]-ghrelin (human) exerts negative inotropic effects in papillary muscle and displays cardioprotective activity, inhibits cell proliferation in breast and prostate cancer cell lines and promotes adipogenesis in vivo.

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