[Des-octanoyl]-Ghrelin (Human)
£125.00 1mg
Non acylated form of ghrelin.
[Des-octanoyl]-Ghrelin (human) is the more stable, non-acylated and major circulating isoform of ghrelin (human ), with a half-life of 35 min in plasma compared with 10 minutes for acylated ghrelin. Unlike ghrelin, [des-octanoyl]-ghrelin (human) does not bind to the ghrelin receptor (GHS-R1a), or induce growth hormone release. [Des-octanoyl]-ghrelin (human) exerts negative inotropic effects in papillary muscle and displays cardioprotective activity, inhibits cell proliferation in breast and prostate cancer cell lines and promotes adipogenesis in vivo.
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Additional information
| Other Names | Des-acyl ghrelin, Unacylated ghrelin, UAG |
|---|---|
| Three Letter Sequence | H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
| Molecular Weight | 3244.51 |
| Molecular Formula | C141H235N47O41 |
| Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | [Des-octanoyl]-Ghrelin (human), 313951-59-6, GSSFLSPEHQRVQQRKESKKPPAKLQPR, des-acyl ghrelin |