D-K6L9

£135.00 1mg

Antimicrobial and anticancer peptide.

D-K6L9 is a host defence-like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.

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SKU: AM-370 Categories: ,

Additional information

Other Names

Amp1D, Amphipathic 1D

Three Letter Sequence

H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2

Molecular Weight

1803.35

Molecular Formula

C90H174N22O15

Sequence

LKLLKKLLKKLLKLL-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Leucines 3 and 8, and lysines 6,9 and 13 are D enantiomers, C terminal amide

Searchable Words

AM-370, AM370, D-K6L9, Amp1D, Amphipathic 1D, LKLLKKLLKKLLKLL-NH2