Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Antimicrobial and anticancer peptide.

D-K6L9 is a host defence-like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.

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