Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

C3 convertase inhibitor.

Compstatin, a cyclic tridecapeptide, discovered from a phage-display library, is a highly potent and selective complement component 3 (C3) inhibitor, binding to C3, C3b, and C3c, but not to C3d. Compstatin binds to C3 in a reversible manner and inhibits proteolytic cleavage by C3 convertase to the proteins C3a and C3b and consequent activation of classical and alternative complement pathways. Compstatin accordingly acts as a complement inhibitor and prolongs graft survival and reduces hyperacute rejection of pig kidneys perfused with human blood, and inhibits in vivo heparin/protamine induced complement activation in primates.

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