Compstatin

£125.00 1mg

C3 convertase inhibitor.

Compstatin, a cyclic tridecapeptide, discovered from a phage-display library, is a highly potent and selective complement component 3 (C3) inhibitor, binding to C3, C3b, and C3c, but not to C3d. Compstatin binds to C3 in a reversible manner and inhibits proteolytic cleavage by C3 convertase to the proteins C3a and C3b and consequent activation of classical and alternative complement pathways. Compstatin accordingly acts as a complement inhibitor and prolongs graft survival and reduces hyperacute rejection of pig kidneys perfused with human blood, and inhibits in vivo heparin/protamine induced complement activation in primates.

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SKU: PI-270 Categories: ,

Additional information

Three Letter Sequence

H-Ile-*Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-*Cys-Thr-NH2 (disulphide bridge between cysteines 2 and 12)

Molecular Weight

1550.77

Molecular Formula

C66H99N23O17S2

Sequence

ICVVQDWGHHRCT-NH2

Solubility

Soluble to 2 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide, disulphide bridge between cysteines 2 and 12

Searchable Words

Compstatin, PI-270, PI270, 206645-99-0