Bak BH3
£85.00 1mg
Bak BH3 sequence that binds to Bcl-xL.
Bak BH3 corresponds to amino acids 72 – 87 in the BH3 region of human Bak and is the minimal sequence for binding to Bcl-xL (B-cell lymphoma-extra large), a transmembrane molecule in the mitochondria which is a member of the Bcl-2 family and key regulator of apoptosis. Bak BH3 has high affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function. Bcl-2 is a potent suppressor of apoptosis, and its overexpression contributes to tumourigenesis in many types of human cancers.
Please contact us for availability.
Additional information
| Other Names | Bak BH3 peptide, BAK peptide |
|---|---|
| Three Letter Sequence | H-Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg-OH |
| Molecular Weight | 1724.93 |
| Molecular Formula | C72H125N25O24 |
| Sequence | GQVGRQLAIIGDDINR |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | GQVGRQLAIIGDDINR, Bak BH3, 300349-67-1, PP-060 |