A11
£145.00 1mg
ANXA1 EphA2 interaction blocker.
A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11
blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing ?Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenic mechanism of the ANXA1 EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo.
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Additional information
| Other Names | ANXA1-derived 11 amino acid “long peptide" |
|---|---|
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH |
| Molecular Weight | 2767.19 |
| Molecular Formula | C117H204N46O32 |
| Sequence | YGRKKRRQRRREYVQTVKSSKG |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | A11, ANXA1-derived 11 amino acid “long peptide, YGRKKRRQRRREYVQTVKSSKG, PP-250, PP250 |