SHBG141-161
£135.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
GPRC6A agonist.
SHBG141-161 is a peptide corresponding to amino acids 141-161 of sex hormone binding globulin (SHBG), the loop region of SHBG connecting ?-strands 11 and 12. SHBG141-161 is an agonist of the class C orphan G protein coupled receptor GPRC6A, a major regulator of energy metabolism and male fertility, and SHBG141-161 competes for binding to it with its endogenous ligand undercarboxylated osteocalcin (ucOCN). In vitro, SHBG141-161 stimulates insulin secretion from ?-cells and also the production and release of testosterone from Leydig and Langerhans ?-cells cell lines.
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Additional information
| Other Names | SHBG(141 “161) domain peptide, SHBG(141 “161) |
|---|---|
| Three Letter Sequence | H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH |
| Molecular Weight | 2145.66 |
| Molecular Formula | C103H173N25O24 |
| Sequence | IALGGLLFPASNLRLPLVPAL |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | OR-030, OR030, SHBG141 “161, IALGGLLFPASNLRLPLVPAL, |