Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

4.3.3 proteins antagonist.

R18, also known as R18 peptide is an antagonist of 14.3.3 proteins, a family of conserved regulatory molecules that have the ability to bind a multitude of functionally diverse signalling proteins, with a KD of approximately 80 nM. R18 competitively inhibits 14.3.3 ligand interactions without requiring phosphorylation and can block the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

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